PR4100 RAM requirements for paired Modules

Hello,
Can someone confirm whether paired RAM modules are required for the PR4100?
The manual suggest so, but good to know if this is really the case.
i.e. if I obtain a single 8GB module, can I use it on its own, or in combination withe one of the modules already installed?

They need to be paired.

I made a post as well can someone see if this memory will work Memory compatibility check