Can it work? Likely yes. But there may be/are better options. Note that if a drive isn’t designed for NAS use (like the WD Red line of NAS drives or Seagate Ironwolf line of NAS drives) one may end up having the hard disk drive fail faster in a NAS/My Cloud than it would under normal desktop usage.
And another issue is the SMR vs CMR. Generally SMR drives are not recommended for use in a NAS for a number of reasons. Seagate indicates (https://www.seagate.com/internal-hard-drives/cmr-smr-list/) their Barracuda drives 2GB-8GB are SMR drives. CMR is best when it comes to NAS drives.
Hard disk drives up to 12TB or more should work in a single bay/single drive My Cloud enclosure. Some past experimentation from a few years ago with WD hard disk drives:
#WDUserRewards
