WD Smartware and Apple Airport Extreme

I have a My Book that I have connected to an Airport Extreme, I can access it as a share drive but I cannot run WD Smartware for automatic back up.  Is this possible to do or will it only work as a share drive while connected to the router?

When connected to the router it will only work as a share drive. 

The only drive that work with Smartware from the Network is My Book Live.

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