I wanted to use Portable Hard drive for 24x7

I wanted to use Portable Hard drive for 24x7 and programs will run from portable drives.
Is it recommended or will create any problem in future ?

Hello,

I don’t recommend installing software on the external drive. This may cause some issues while booting if the drive is not plugged in.

Hello,
Thanks for reply but is it recommended to connect portable Hard drive 24x7
to PC? It will create any issue with drive?

Awaiting for reply.