Drive Capacity for EX4100

I have 3 EX4100’s. The first one I recently upgraded from 6 tb hdd to (4) 14 TB Ultrastar WD HC530 and things see to be working very well. The other 2 systems have (4) 8 TB HDD installed. Mostly using for storage of HD (720p and 1080p) and UHD video files. Just purchased (4) 16 TB drives to upgrade one of the others. I am hoping that the 16 TB drives will work. So the question is, has anyone else successfully used the larger capacity drives? If so what are the pitfalls? The system with the 14 TB drives seems to be working fine at this point.