You will need to get a backup software that schedules backups (Windows 7 has one). Then once you set it, configure Windows Power Management to turn off hard drives after a certain amount of inactivity. When the scheduled backup starts, it should wake up the drive. Of course, turning off the drives will turn of your system drive as well. Otherwise, schedule the backup and just wait. The My Book Pro should shut off after about 10 minutes. If it doesn’t, then it’s because there’s software or some utility that’s hitting the drive every so often and keeping it awake.