Turning off Harddisk in Power Option

For server setup, should I disable the hard disk turn off option in Power Option (Control Panel)? I read somewhere that the reliability of the drive is impacted if the spin down and spin up drive happens a lot. If my server is 24/7 running, what would be the best setting for this option?

This is drive-specific based on your personal needs. Some drives are factory-optimized for 24/7 usage, while other devices prioritize power saving.