Could not find any useful info through Google.
And I don’t see patterns how these files are generated.
On Windows 10, thumbs.db are hidden files created when using thumbnail previews for folders in File Explorer.
Although these files are harmless, sometimes they can cause problems. For instance, if you moved content from a Windows 10 device to a network shared, and then you want to delete a folder, you may end up with a “The action can’t be completed because the file is open in Windows Explorer” message referring to the “thumbs.db” file that will prevent you from removing the folder.
not sure about the encryptable part ?