My Passport usable on Mac Panther?

Does anyone know if the 250GB My Passport can be used on Mac OS 10.3.8 Panther, assuming you’ve already reformatted it on Mac Tiger or Leopard? In the past I’ve found that Panther is capable of using some things that are not advertised for it.

We no longer support Panther, but if it can read the drive, then why not.