My Passport Ultra interferes with my internal and external speakers

It has to do with RFI (radio frequency interference) Your devices are too close to one another most likely. USB3 drives can cause this issue. See this link about another RF problem with a drive. Notice the reference to an Intel study about RFI with wireless signals and USB3 drives. Look at the Intel whitepaper. Not exactly your problem, but it does concern RFI and USB3 ports with drives attached.