Is it safe to reinstall apps while Indexing?

My EX2 Ultra has been indexing for close to two days since I did the foolhardy upgrade to OS 5. From what I see from others, it’s just getting started, and may take over a week.

Is it safe to reinstall my apps while this is still happening? My Apps tab still shows “loading”. Can I reinstall Plex on my own without damaging anything? And will it pick up my settings from the previous install?