The following issues have been addressed per firmware release thus far.
5.12.108 fixed the every 24 hour wake up
5.11.112 fixed the every 12 hour wake up
5.07.118 fixed the every 1 hour wake up
Third party apps such as GoodSync, Plex, Twonky, etc are managed by the app vendors and can also wake up the drives. SMB (samba), AFP, mobile app auto backups and anything scanning or polling the network attempting to access shares can wakeup the drives as well.
