Elements 3TB USB3.0 external drive as Internal?

I am about to take the elements 3TB usb3.0 drive out from the case and use it as an internal drive. Can a general Desktop PC recognize it when I connect a SATA cable to it?

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The internal drive could be a native USB drive, making a PC connection rather difficult.

Here’s a teardown video of a WD Elements 2TB 3.5 inch …

Looks like a standard SATA connection to me after you remove the USB board