Back then, when I bought my EX4100, that system did support at most two volumes: from which at least one had to be a spanning volume, containing all the disk space not assigned to the other volume for which of course RAID 0, 1, 5, 10 were allowed. To my knowledge the specs have not changed since.
Although I was able to define more than one RAID 0, 1, 5, 10 volumes, the system did not support that configuration on all error situations tested by me. Therefore: you possibly are on your own, when you do define more than one RAID 0, 1, 5, 10 and an error strikes your EX4100 or one of your disks.
In addition: your two 4TB-disks are becoming old! What about mirroring each in one of the two 10TB-disks and combine both pairs within a RAID 10? One might recognize the upgrade-path to a RAID 10, where each of the disks holds at least 10TB.