Bootable clone m.2 NVME no working

I have produced several clones with a USB to m.2 NVME external case adapter that supposedly completed the process. When I remove the old boot drive and insert the M.2stick into the MOBO slot the system will not boot up normally. Tried Boot manager and still no luck. Is there an issue with the way you produce the clone for a desktop or is Acronis just that buggy?