4TB Blue SSD keeps disappearing from Windows/BIOS

I purchased a 4TB WD Blue SATA SSD three weeks ago, and its disappeared overnight from Windows 10 file explorer (and BIOS) 3 times after formatting and being placed into service. It’s the third disk in my system and replaces a 2TB spinning Hitachi (a secondary, non-bootable drive). I used the same SATA data cable and power supply connector as the Hitachi for the Blue. After a week of use, the first time the Blue disappeared overnight it was in use by a program (not idle or sleeping). I swapped its position with my DVD player (swapped data cable and power connector) and it booted fine. SMART says nothing is wrong with the drive. So I moved it back to its old spot and that also lasted about a week. The second time it disappeared overnight it was idle. So I completed replaced the SATA cable with a new, unsed one. I also move the Blue to a never used power supply connector. That lasted just one night. Again overnight it disappeared. Two reboots and its still missing in Windows and BIOS. The SATA cable and power supply connector appear snug and tight, but after simply touching them a little, the Blue will come back after a boot. Its like a short is occurring but I don’t see how it’s not a fault in the Blue with me using 2 different SATA data cables and 2 different power supply connectors. A pair of which worked fine for years on a Hitachi drive. BTW, the Blue came with the latest firmware according to WD Dashboard.

Which motherboard are you using?
Some motherboards can be very critical when using SSD’s

Asus Z97-A

Changing cables is the first option, but you did that already many times.
What’s happening if you connect the 4TB WD Blue SATA SSD to your computer by use of USB-docking.

I’m coming to realize the Blue disappears during a system backup each night. I use Easeus ToDo Backup. I got a successful full backup on all drives (including the Blue which is about half full) at the end of May to an external USB drive. Then I got several days (almost a week) of successful nightly incremental backups. But for 3 days in a row the backups failed (I think it again was trying to read all the data for a full backup). The backups start at 1am and fail before completion because the drive disappears from Windows. Above logs show one failure at 1:16 and another at 5:21 so the timing isn’t consistent.

The Blue won’t reappear to Windows or the BIOS with a warm reboot. It takes a cold boot to get the drive back. So the question is this a Blue problem (being a new drive) or is this my system of like 6 years (containing another SSD and HDD)? I’ve returned the drive so I can try again with another Blue.