4096 bytes-per-sector internal, 512 bytes-per-sector external

i have new Western Digital HDD ith 4096 bytes-per-sector in pc
and external backup ( USB ) HDD with 512 bytes-per-sector.
Is there any data transfer conflict betveen those HDD`s.

For example cloning 4096 bytes-per-sector hdd to hdd 512 bytes-per-sector
is not good idea.( with sata cables, and cloning software…)

But is it different thing when using usb connected external HDD, i mean posible data corruption
becouse of different sector sizes. Not cloning, only data backup and file transfer between those HHD`s.

thank you

Regular file transfer is not a problem. Just cloning would be an issue due the different sector size.