I have read many people having problems Streaming DVD and Bluray ISO to WDTVLiveHub.
The best thing to do is, copy the entire ISO to the built in Hard Drive
Or use a Network Share.
You cannot use DLNA Media Server for this as ISO is a disk image and not a streaming file format.
It is not WDTV Live Hub problem. Search them on a Network Share. Twonky and DLNA etc will not do it.
I hope I helped someone out today.