Backup & Retrive buttons cannot be pressed in WD Smartware

Hello, first verify if the external drive is recognized by the PC. You can also try uninstalling Smartware and doing a clean instaltion of the latest version. 

How to uninstall WD SmartWare Version 2.2.x and earlier from Windows (8, 7, Vista, or XP) and Mac OSX (10.4, 10.5, 10.6, and 10.7) 

Latest Smartware version. 

http://www.wdc.com/wdproducts/wdsmartwareupdate/