If you have already run Ccleaner on your OC it may have remove something important. You need to use care when running any of these registry cleaner products. When I run it I use the default settings and save when the option pops up before deleting. I use the free version and there is no option to clean other drives. I doubt it would do much anyway it cleans up temp files and registry items left behind when installing, updating, and uninstalling software.
Joe
