My Book 2TB USB3 drive becoming inaccessible when used with Norton Ghost

I have now tried installing Ghost on another PC and succeeded in doing a full disk backup to the My Book. However there are differences between this system and the system I had problems on: (1) this new PC runs XP, (2) I am using a USB2 connection, (3) I did not allow the installation of the SES driver when I attached the My Book drive - i.e. I am using the Windows generic driver. Don’t know if any of this makes a difference.