Featoffun,
A few things to try (in order to try):
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make sure the unit’s firmware is up to date. There is a Universal FW Updater avaliable, off the WD Support site. I just updated a couple units I had. Updates MUST be done when connected using USB. Updating doesn’t work if connected using Firewire or eSATA.
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Update your WD Drive Manager. The latest version I find on the WD Support site is version 3.1.0.14.
OS-X’s Disk Utility should be able to undo MBR (thats will limit the supported size to 2.2TB). Try partitioning as HFS instead of MS-DOS or ExFAT. That should clear the MBR and use GUID partitioning.
I have had no problems getting 4TB drives to work in the MyBook Studio Edition II after updating.
Enjoy!