I am sure the default configuration that came with the drive is the most optimal for it.
Common sense tell me that constant spin up and down (imagine you accelerate your car, press the brake, and repeat the cycle again nonstop - it’ll shorten your car’s life, and probably yours too :P) could shorten its life, but as I said, if it’s rarely used, it’s probably better to spin down to reduce heat. I have some older drives that don’t have the autopark/spin down feature but some lasts above 30k hours. They’re rarely used though, perhaps only 2-3 hours a day.
